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Tretinoin is used to treat acne and other skin disorders as prescribed by your doctor. It works by keeping the skin pores free. One tretinoin cream is used to address fine wrinkles, dark spots, and rough skin on the face produced by the sun's harmful rays.Retinoids, which are derived from vitamin A, such as tretinoin (Retin-A, Renova, Avita), can help to improve the appearance of stretch marks that are less than a few months old. Tretinoin, when it works, helps to rebuild a protein in the skin called collagen, making the stretch marks appear more like your regular skin.