DIFFERIN Gel (Adapalene 0.1%) is an FDA-approved, dermatologist-developed OTC retinoid that treats and prevents acne by regulating cell turnover, unclogging pores, and reducing inflammation. It effectively clears blackheads, whiteheads, and pimples on the face, chest, or back, while also improving skin texture, fading dark spots, and promoting long-term skin health.