68 Eduardo Mohdlana Mamprobi Sempe Rd, Accra Ghana
From Circle pick Sempe Car, From Tema station pick Mamprobi car.
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Typhoid fever is a life threatening illness caused by the bacterium
Salmonella typhus, and was observed by Eberth (1880) in the mesenteric
nodes and spleen of fatal cases of typhoid fever. It is common in developing
countries where it affects about 12.5 million persons annually. The infection
is acquired typically by ingestion. On reaching the gut, the bacilli attach
themselves to the epithelial cells of the intestinal villi and penetrate the
lamina and submucosa. They are then phagocytosed there by polymorphs
and mesenteric lymph nodes, where they multiply and, via the thoracic duct,
enter the blood stream. A transient bacteremia follows,during which the
bacilli are seeded in the liver, gall bladder, spleen, bone marrow, lymph
nodes, and kidneys, where further multiplication takes place. Towards the
end of the incubation period.